The status quo of DMT in prevailing science, despite the compound’s visionary properties, is that DMT is a by-product of metabolism. 5-MeO-DMT (5-methoxy-dimethyltryptamine) is, like DMT, a psychedelic agent. The stems contain roughly the same set, excluding bufotenine. cabrerana doesn’t only contain DMT (between 0.17 and 1.75% of the leaves), but also N-methyltryptamine, 5-MeO-DMT, bufotenine and N-methyltetrahydro-β-carboline. Intra-muscular and intravenous administration is effective without an MAOI. Oral administration of DMT after a corresponding amount of MAOIs causes an experience of at least 3 hours. Nasal insufflation, which is an important tradition of the Yanomamo tribe (see Wikipedia’s Yopo page) of DMT causes an experience that lasts up to 60 minutes. Inhalation causes effects that last up to 30 minutes. The same goes for parenteral administration (injecting). When inhaled through a vaporizer or bong, DMT gives pronounced effects without the intervention of an MAOI. Outside the nervous system 5-HT 2A receptors are present in platelets (cell fragments, circulating in the blood, that are involved with clotting) and some muscles. Inside the nervous system these are located near most of the serotoninergic terminal rich areas, including the neocortex (mainly the prefrontal, parietal, and somatosensory cortex) and the olfactory tubercle. The β-carbolines in the vine temporarily inhibit the production of this enzyme, allowing the DMT to reach the sensitive parts while still active. When humans take DMT by itself orally, it is converted into inactive aldehydes by the endogenous enzyme monoamine oxidase. DMT is, like LSD, a partial-agonist on the receptor subtype 5-HT 2A. It has a similar structure to serotonine and thus has affinity for several serotonergic 5-HT 2 receptors. Tests of different samples of Amazonian brews have found 25 to 36 mg of N,N-DMT per dose. cabrerana leaves is the indole ethylamine alkaloid n,n-dimethyltryptamine. PSYCHOTRIA VIRIDIS AND DIPLOPTERYS CABRERANA These compounds are present in many kinds of food, like cheese and ripe fruit. Apart from creating a path for otherwise orally inactive tryptamines, this renders certain substances harmful, most notably tyramine and tryptophan. Harmine and other MAO-inhibitors prevent the breakdown of monoamine neurotransmitters by inhibiting the action of monoamine oxidase enzymes. caapi are harmine-N-oxide, harmic acid methylester, harmalinic acid, harmic amide, acethylnorharmine and ketotetrahydronorharmine. Tests of different samples have found 20 to 40 mg, 144 to 158 mg, and even 401mg of β-carbolines per dose. In the recipes of the Amazonian Indians, the liana itself is typically the main ingredient. harmala seeds, so ‘telepathine’ has become obsolete. Later scientists discovered they had already come across the same compound in P. They all belong to the β-carbolines group, which implies they are MAO-inhibitors. caapi are the alkaloids harmine, harmaline and tetrahydroharmine. The plant sources, the chemical processes and psychopharmacological actions described below are the ones that are generally considered to be the most remarkable ones. There’s a uniquely vast array of botanical sources, and an infinite amount of preparation methods, usually involving psychoactive compounds that we’re only beginning to comprehend scientifically, such as DMT and 5-MeO-DMT. 2D image of a harmine molecule 2D image of a dimethyltryptamine moleculeĪyahuasca is as complex as both chemistry and psychopharmacology can get.